Hepa 1-6: A Murine Model of Hepatocellular Carcinoma

Hepatocellular carcinoma (HCC) is an aggressive malignancy which has gradually increased in incidence to affect one million people worldwide and is currently the third leading cause of cancer related deaths in the world.[1,2] The prevalence of HCC is highest in Asia and Africa due to high endemicity of hepatitis B and C viruses which strongly […]

HCC70: A Model of Triple Negative Breast Cancer

Table 1: Endpoint Analysis Following Treatment with Paclitaxel and Focal Radiation Group # Treatment Related Weight Change Median % ΔT/ΔC (day 63) % Regression (day 63) % Complete Regression % Partial Regression % Tumor Free Survivors Vehicle 4.8 100 0 0 0 0 Paclitaxel 4.4 72.2 0 0 0 0 […]

Utilization of Preclinical Radiation in Oncology Mouse Models

Webinar Description: More than 50% of all cancer patients receive some sort of radiation therapy as part of their disease treatment plan. However, there remains a persistent lack of drug development with radiation combinations. In order to venture into clinical trials many drug developers want and need preclinical validation of […]

Sensitivity of Syngeneic Tumor Models to Focal Radiation

Introduction and Background Use of image-guided focal irradiation is a mainstay of human cancer treatment. Image guidance allows for highly conformal treatment plans that minimize normal tissue toxicity and systemic response. With the advent of image-guided small animal irradiators such as the Small Animal Radiation Research Platform (SARRP; Xstrahl Inc., […]

Utilization of Radiation in the Preclinical Oncology Setting

The American Cancer Society estimates that in 2017 over 1.6 million people will be diagnosed with non-skin cancers in the United States. It is known that more than 50% of all cancer patients will receive some sort of radiation therapy as part of their treatment plan. Why is it then that preclinical evaluation of drugs […]

Focal Radiation in the Murine 4T1-luc2 Mammary Cancer Model

The use of immuno-oncology therapies have seen remarkable progress in the last five years and are currently undergoing clinical trial use in combination with a variety of agents including radiation therapy (RT).1 RT is a main-stay in clinical oncology treatments with approximately 60 percent of cancer patients receiving RT at some point during their care. […]

Access the Power of Focal Beam Radiation Using Xstrahl’s SARRP

Xstrahl’s SARRP (Small Animal Radiation Research Platform), incorporates CT imaging with precise radiation delivery to enable researchers to pinpoint an exact anatomical target. This small animal irradiator can then deliver single or multiple beams of radiation to the target with the upmost accuracy, matching the clinical techniques used in oncology […]