Covance offers in-house histology and immunohistochemistry (IHC), further expanding our extensive list of services to enhance your study. We are committed to making your outsourcing as easy and streamlined as possible. Optimal preservation and structural integrity of your samples is ensured by simply moving samples down the hallway from the vivarium to the histology lab in our state-of-the-art facility. Quality imaging for analysis is achieved using the Aperio VERSA Brightfield Fluorescence Digital Pathology Scanner. MI offers a full suite of histology and IHC services, including custom work, and will be adding markers routinely.
Our high-quality IHC assays give you a time-efficient read-out on quantitative and qualitative data and can be produced expeditiously that reveal the following:
- Efficacy of your compound in target tissues
- Location of biomarkers in tissues
- Incidence of tumor metastasis
- Occurrence of tissue transformation into tumors
- Origin of tumor tissue
- Prognosis of the animals in the study
Featured IHC Articles:
- Normal Tissue
- Tumor Tissue
- New Marker Validation
- Multiplex – Custom markers with up to four-color immunofluorescence
Validated IHC Markers:
Mouse CD3 membrane staining in spleen. CD3 is used to identify T cells in normal tissue, as well as T cell neoplasms.
Mouse CD4 membrane staining in mouse tumor tissue. CD4 is used to identify T helper cells, and plays a role in T cell activation.
Mouse CD38 staining in multiple tissues, as indicated. CD38 is found on the surface of many immune cells (CD4+ and CD8+ T cells, B cells, and natural killer cells). It has functions in cell adhesion, signal transduction and calcium signaling and is used as a prognostic marker in leukemia patients with CLL.
Mouse CD163 staining in multiple tissues, as indicated. CD163 is expressed in macrophages and monocytes. Expression may be indicative of inflammation.
Her2 is a human EGF receptor involved in kinase mediated activation of signaling pathways. It is used as a predictive factor and determinant in therapy in cancer treatment.