GL261-luc: A Model for Immunotherapy and Radiation Therapy

Glioblastoma multiforme (GBM) is the most aggressive form of brain cancer. GBM tumors grow within a fairly immunosuppressive tumor microenvironment and a relatively immune-privileged central nervous system. For patients diagnosed with GBM, prognosis remains poor with conventional therapies that include radiotherapy, chemotherapy, and surgery. Immunotherapy drugs provide an alternate approach […]

Evaluation of the Immune Response Following Treatment with Anti-CTLA-4 Antibody, Radiation Therapy, or the Combination in Murine Model of Breast Cancer

Breast cancers are considered poorly immunogenic tumors, however, several approaches utilizing immunotherapies are being undertaken in the clinic to evaluate their potential for improving outcomes. Radiation therapy (RT) is a highly utilized clinical treatment modality in breast cancer. Radiation is known to modify the tumor microenvironment, induce cytokines and chemokines, and has been shown to […]

Access the Power of Focal Beam Radiation Using Xstrahl’s SARRP

Radiation therapy is one of the most common treatments for cancer. Approximately 60 percent of cancer patients will receive radiation treatment at some point during their care. Its clinical prevalence makes understanding how novel cancer treatments may synergize with radiation therapy vital to drug development. Radiation therapy treatment uses high-energy […]

GL261: Syngeneic Murine Glioma Model

Glioblastomas are known to have a poor prognosis with median survival of nine months and only five to 10 percent of patients surviving up to two years. Conventional therapies include radiotherapies and surgical removal of the tumor in combination with chemotherapy. Unfortunately, these tumors can often be radioresistant and surgical […]