Longitudinal Evaluation of Orthotopic Lung Tumors With Imaging

Clinical imaging technologies have been vital for detecting and following disease progression/regression for many years, as examples, Computed Tomography (CT) can measure tumor volume over time and Positron Emission Tomography (PET) can measure metabolic activity within the tumors. At MI Bioresearch we have been utilizing preclinical imaging technologies for over […]

PET Quantification of Receptor Occupancy

The use of PET imaging to detect and quantify receptor occupancy (RO) has become a translational standard in CNS discovery and clinical trials. For example, 18F radiolabeling of targeted small molecules enables a PET tracer-based PD biomarker. The tracer can be used for dynamic, non-invasive quantification of percentage RO. For relevant targets, rodent models can […]

Precision Imaging of Antibody Biodistribution in vivo With Zirconium-89 PET

Zirconium-89 (89Zr) has revolutionized discovery and translation of Ab (and Ab fragment) therapeutics via PET biodistribution imaging.  With standard, straightforward labeling chemistry, 89Zr provides unprecedented specificity and sensitivity of PET Ab detection (to pM levels).  At MI Bioresearch we use 89Zr PET as a platform assay for in vivo quantification of: Ab targeting precision Off […]

Quantifying in vivo Biodistribution and Kinetics of Your Biologic or Nanomaterial

With the ability to provide non-invasive, three dimensional, longitudinal, and quantitative data—PET, SPECT, and fluorescence imaging (FMT) enable translational imaging of: Biodistribution Targeting Kinetics Clearance Pathways In vivo biodistribution imaging applications are now critical assays for biologics characterization for discovery screening, lead candidate selection/optimization and safety. At MI Bioresearch (MI) we combine highly sensitive PET, SPECT, […]

Advancing Discovery and Development of Biologics Through Non-Invasive Biodistribution Imaging

With the ability to provide non-invasive, three dimensional, and quantitative data; PET, SPECT, and fluorescence imaging (FMT) enable translational imaging of biodistribution, molecular and cellular targeting, competitive binding and PK/PD. These imaging applications have become critical assays for biologics characterization for discovery screening, lead candidate selection, optimization and safety. The use of imaging-based biodistribution applications […]