In addition to our focus in oncology, MI Bioresearch works across a variety of relevant rodent models of human disease—particularly when our broad range of sophisticated tools (especially in vivo imaging) can provide a distinct advantage over traditional methods.
The below matrix provides examples of applications we have experience with.
|PET/CT||F18 PET imaging of neuro-receptor occupancy|
|PET/CT||FDG-PET imaging of brain metabolism|
|SPECT/CT||Tc99 SPECT imaging of neuro-receptor occupancy|
|Parkinson’s Disease||SPECT/CT||I123 DaTscan imaging of dopamine transporter|
|Stroke||MRI||Infarct volume in tMCAO stroke model|
|Bone related||CT||High resolution micro-CT of bone in vivo and ex vivo|
|FLI||Assessment of osteoclast activity by FLI imaging of Cathepsin K using the Cat K 680 FAST fluorescent imaging agent|
|Acute Inflammation||MRI||F19 MRI imaging of macrophages in acute inflammation (sponge granuloma)|
|MRI||Quantitation of hypercellularity by ADC MRI in models of renal fibrosis|
|CT||Quantitation of tissue density in the lung in models of pulmonary fibrosis|
|MRI||In vivo tracking of therapeutic cells using F19 reagents or USPIO in naive or disease model rodents|