MI Bioresearch offers in-house histology and immunohistochemistry (IHC), further expanding our extensive list of services to enhance your study. We are committed to making your outsourcing as easy and streamlined as possible. Optimal preservation and structural integrity of your samples is ensured by simply moving samples down the hallway from the vivarium to the histology lab in our state-of-the-art facility. Quality imaging for analysis is achieved using the Aperio VERSA Brightfield Fluorescence Digital Pathology Scanner. MI offers a full suite of histology and IHC services, including custom work, and will be adding markers routinely.

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Validated IHC Markers:

AE1/AE3+5D3

AE1/AE3+5D3 cytoplasmic positive mouse skin. Cytokeratin's are filamentous proteins detectable in epithelial cells. They can be utilized in tumor differentiation, cell typing, and micrometastasis.

AE1/AE3+5D3 cytoplasmic positive mouse skin. Cytokeratin’s are  filamentous proteins detectable in epithelial cells. They can be utilized in tumor differentiation, cell typing, and micrometastasis.

CD3

Mouse CD3 Membrane staining in spleen. CD3 is used to identify T cells in normal tissue, as well as T cell neoplasms.

CD4

CD4

Mouse CD4 membrane staining in subcutaneous A20 mouse tumor tissue. CD4 is used to identify T helper cells, and plays a role in T cell activation.

CD8

CD8

Mouse CD8 membrane staining in subcutaneous CT26 mouse tumor tissue. CD8 is used to identify cytotoxic T cells.

CD19

CD19_Fluorescence

Human CD19 membrane staining in human tonsil. CD19 is a biomarker for B cells, and plays a role in B cell development.

CD45

Mouse CD45 membrane staining in A20 tumor tissue. CD45 plays a role in the regulation of T- and B-cell antigen receptor signaling.

Mouse CD45 membrane staining in A20 tumor tissue. CD45 plays a role in the regulation of T- and B-cell antigen receptor signaling.

ER

FoxP3

FoxP3

Mouse FOXP3 Nuclear staining in Spleen. FoxP3 is involved in the development and inhibitory function of regulatory T cells.

HER2

HER2 with arrows

HER2_Fluorescence

Her2 positive cytoplasm in BT474 tumor tissue. Her2 is a human EGF receptor involved in kinase mediated activation of signaling pathways. It is used as a predictive factor and determinant in therapy in cancer treatment.

Ki67

Ki67 positive tonsil tissue, with localization dominant in the nucleus. The Ki67 protein Is associated cellular proliferation, and therefore can be used as a prognostic tool in cancer.

Human Ki-67 nuclear staining in human tonsil. The Ki-67 protein is associated with cellular proliferation, and can be used as a prognostic tool in cancer.

P53

PR

PR with arrows

Human PR positive nuclei in BT474 tumor tissue. Progesterone receptor is involved in activating signaling pathway for hormone stimulation. It can be utilized in determining appropriate drug  therapy in cancer treatment.

S100