Targeting B Cell Malignancies? Raji-Luc is a Model to Test CD19-Directed CAR-T Cells and Other Novel Approaches

While the direct contribution of CD19 to human B cell cancers is still under investigation, its expression is found on a majority of B cell malignancies. For example, acute lymphoblastic leukemia (ALL), B cell lymphomas, and B cell leukemias demonstrate 80%, 88%, and 100% CD19 expression, respectively.1 ALL presents with an overproduction of lymphoblasts in … Continue reading Targeting B Cell Malignancies? Raji-Luc is a Model to Test CD19-Directed CAR-T Cells and Other Novel Approaches