Preclinical Single Photon Emission Computed Tomography (SPECT) is a flexible and quantitative method for determining biologics biodistribution, kinetics, and targeting. Our SPECT imaging platform allows you to assess early biologic candidates to make better decisions with greater confidence.
SPECT is a 3D nuclear medicine imaging technique that provides qualitative and quantitative physiologic measurements. Detection of a SPECT isotope occurs using gamma detectors, with the detection events being used to tomographically reconstruct a three-dimensional image of the isotope molecule distribution in the whole body.
Key advantages of SPECT imaging:
- Non-invasive imaging of fine kinetics can be examined allowing establishment of a kinetic curve by tissue or even by tissue compartment (heterogeneity)
- Full 3-dimensionality of biodistribution with tissue localization aided by anatomical CT overlay
- Clinical translational
- Tracer multiplexing—multiple isotopes of different energies can be used to address multiple simultaneous questions in the same subjects
In Vivo Biodistribution Imaging With Long-lived SPECT Isotopes
A variety of SPECT isotopes can be used in translational studies to assess test molecule biodistribution, targeting, and kinetics. We are licensed to use a broad array of SPECT isotopes to assess biodistribution of labeled molecules including:
- Antibody fragments
The isotopes we can use cover a variety of labeling methods, half-lives, and imaging properties that can be tailored to specific needs. These include:
|Isotope||Half Life||Energy in KeV||Common Applications/Strengths|
|Technetium-99m [99mTc]||6 hours||140.5||Most common clinical SPECT isotope; bone imaging|
|Iodine-123 [123I]||13.2 hours||159||Neuro-imaging|
|Indium-111 [111In]||2.8 days||171.3, 245.4||Biodistribution|
|Gallium-67 [67Ga]||3.3 days||93.3, 184.6, 300||Translatable to [68Ga] PET radiotracer|
|Lutetium-177 [177Lu]||6.73 days||113, 210||Radiotherapy|
|Thallium-201 [201TI]||12.23 days||135, 167||Cardiac imaging|
|Tin-117m [117mSn]||14 days||158.6||Long-term biodistribution|
|Iodine-125 [125I]||59 days||27 to 32||Iodination|
A broad array of SPECT isotope labeled molecules and tracers are available that can be used to target specific tissues and interrogate disease biology, progression, and response to therapies at the molecular level. These tracers enable translational biomarkers that provide complementary information about drug activity and can be utilized clinically.
We give you access to a broad array of biomarkers of disease progression through commercially available SPECT tracers. Contact us to learn more.